Science Signaling http://stke.sciencemag.org/ Science Signaling, the Signal Transduction Knowledge Environment American Association for the Advancement of Science Nancy Gough (mailto:ngough@aaas.org) Copyright 2009 American Association for the Advancement of Science 2009-01-06T17:47:55-05:00 en Science http://www.sciencemag.org/icons/banner/title.gif http://www.sciencemag.org [Editorial Guide] 2008: Signaling Breakthroughs of the Year http://stke.sciencemag.org/cgi/content/abstract/2/52/eg1?rss=1 This year's signaling breakthroughs extended from protein crystals to cells and subcellular structures to whole genomes. Elizabeth M. Adler [Perspective] MicroRNAs: Opening a New Vein in Angiogenesis Research http://stke.sciencemag.org/cgi/content/abstract/2/52/pe1?rss=1 MicroRNAs regulate angiogenic signaling in endothelial cells. Jason E. Fish and Deepak Srivastava [Perspective] Computational Implications of Cooperative Plasticity Induction at Nearby Dendritic Sites http://stke.sciencemag.org/cgi/content/abstract/2/52/pe2?rss=1 Cooperative interactions at nearby synapses may endow individual neurons with computational functions. Kenji Morita [Journal Club] Drosophila Toll Pathway: The New Model http://stke.sciencemag.org/cgi/content/abstract/2/52/jc1?rss=1 New data has led to reevaluation of the proteolytic cascades that activate Toll in flies. Yashwanth Ashok [Editors' Choice] The Long Way Around http://stke.sciencemag.org/cgi/content/abstract/sigtrans;2/52/ec1?rss=1 Leptin decreases insulin production in part by inhibiting the activity of the insulin secretagogue osteocalcin in an epinephrine-dependent manner. Database of Cell Signaling: Specific Pathway http://stke.sciencemag.org/cgi/cm/stkecm;CMP_14238?rss=1 Arabidopsis Ethylene Signaling Pathway